Th smaller HA crystals because the IDPs that regulate their growth are also altered in structure [141,142,143,144,145,146]. Enamel malformations are also associated with DSPP mutations, although enamel mineralization is not dependent on DSPP [147]. In the Dspp knockout (KO) mice, the teeth are hypo-mineralized [148] and similar to humans with DSPP mutations, the mice develop periodontal disease [1

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